Thursday, 5 December 2024
Eddie Mulcahy
My Father
Monday, 6 February 2023
The Grapefruit Effect
Although I do not have to take any prescribed drugs and do not pay much attention to health-related articles, I was vaguely aware that the word "grapefruit" is often mentioned near the word "medicine." Basically it appears that this citrus fruit can react with many drugs in ways which are not helpful.
I was not aware at all that the "Grapefruit Effect" was one of those "accidental scientific discoveries" and that the discovery occurred here in London when Dr. David Bailey was trying to figure out ways to hide the taste of alcohol from those who were participating in a study he was doing on a blood pressure drug. The solution was grapefruit juice and it was a suggestion from his wife that led to an accidental discovery of considerable significance:
“It was really my wife Barbara and I, one Saturday night, we decided to try everything in the refrigerator,” says Bailey. They mixed pharmaceutical-grade booze with all kinds of juices, but nothing was really working; the alcohol always came through. “Finally at the very end, she said, ‘You know, we’ve got a can of grapefruit juice. Why don’t you try that?’ And by golly, you couldn’t tell!” says Bailey. So he decided to give his experimental subjects a cocktail of alcohol and grapefruit juice (a greyhound, when made with vodka), and his control group a glass of unadulterated grapefruit juice.
The blinding worked, but the results of the study were … strange. There was a slight difference in blood pressure between the groups, which isn’t that unusual, but then Bailey looked at the amount of the drug in the subjects’ bloodstreams. “The levels were about four times higher than I would have expected for the doses they were taking,” he says. This was true of both the control and experimental groups. Bailey checked every possible thing that could have gone wrong—his figures, whether the pharmacist gave him the wrong dosage—but nothing was off. Except the grapefruit juice."
Dr. David Bailey and Western University
"Grapefruit’s medication-concentrating powers were discovered only because of a culinary accident. Some three decades ago, the clinical pharmacologist David Bailey (who died earlier this year) was running a trial testing the effects of alcohol consumption on a blood-pressure medication called felodipine. Hoping to mask the distinctive taste of booze for his volunteers, Bailey mixed it with grapefruit juice, and was shocked to discover that blood levels of felodipine were suddenly skyrocketing in everyone—even those in the control group, who were drinking virgin grapefruit juice.
After running experiments on himself, Bailey confirmed that the juice was to blame. Some chemical in grapefruit was messing with the body’s natural ability to break down felodipine in the hours after it was taken, causing the drug to accumulate in the blood. It’s the rough physiological equivalent of jamming a garbage disposal: Waste that normally gets flushed just builds, and builds, and builds. In this case, the garbage disposal is an enzyme called cytochrome P450 3A4—CYP3A4 for short—capable of breaking down a whole slate of potentially harmful chemicals found in foods and meds. And the jamming culprit is a compound found in the pulp and peel of grapefruit and related citrus, including pomelos and Seville oranges. It doesn’t take much: Even half a grapefruit can be enough to trigger a noticeable interaction, says George Dresser, a pharmacologist at Western University, in Ontario."
Additional information about the "Grapefruit Effect" and Bailey is provided below.
Also An Athlete
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Bailey is on the right. Medalists in the 1500-metre run at the Winnipeg Pan Am Games. |
At the age of nine, David Bailey lost an eye in an accident and his participation in sports was limited to running. He became quite good at it. His athletic achievements are noted in his Globe and Mail obituary and are provided here:
A Brief Bailey Bibliography
Obituaries: (with some excerpts)
1. Dr. David George Bailey, PhD, Mar. 17, 1945 - Aug. 27, 2022,
Westview Funeral Chapel
"David distinguished himself for two very different reasons in the world of international running, as well as food-drug research. On June 11th, 1966, in San Diego, CA, he became Canada’s first sub-four minute miler in a time of 3:59.1. He sought to top this a year later on July 22, 1967, this time in his home town of Toronto, ON, in a time of 3:57.7. Later in his life, while working on a clinical pharmacology study between a blood pressure lowering drug and alcohol, he discovered the bizarre reaction between some medications and grapefruit juice. So if you ever see a little sticker on your medicine bottle saying “don’t take with grapefruit juice” you can thank Dr. Bailey."
"22 Influential People Who Died in 2022..." Dec. 31, 2022.
U.S. - "Grapefruit Juice and Some Drugs Don't Mix."
"Grapefruit and Medication: A Cautionary Note," Harvard Health Publishing, Mar. 30, 2021.
Tuesday, 30 August 2022
Graham Murray
In Memoriam
"Mr. Queen's Park"
Saturday, 28 May 2022
James Francis Edwards - Canadian Fighter Pilot
That picture caught my attention when I saw it in an obituary in the Washington Post. The handsome fellow is the Canadian 'Stocky' Edwards who just died out on Vancouver Island in the Comox area. He would have been 101 on June 5. Here is a bit from the long obit:
With the rank of wing commander, Mr. Edwards shot down a confirmed 19 Luftwaffe fighter planes and scored many more “probables,” the aircraft he put out of action but did not see hit the ground. He also destroyed at least 12 more enemy warplanes at their desert bases before they could take to the air…..
In all, he flew 373 combat missions during World War II, mostly over North Africa but also to provide air support for the Allied landings in Italy in 1943 and 1944 and in Normandy on D-Day — June 6, 1944 — a rare “triple” among Allied pilots….
In addition to the Distinguished Flying Cross, awarded by the United Kingdom during the war, Mr. Edwards was named to the Order of Canada, one of that nation’s highest awards, in 2004. He was inducted into Canada’s Aviation Hall of Fame in 2013 and the following year was appointed to France’s Legion of Honor by President François Hollande for his services to France during the war.
More death notices are found in a number of Canadian newspapers in mid-May of this year and there is a good Wikipedia entry for him, so I need not go on. I just thought it worth noting the passing of this real, Canadian "Top Gun" since the newspapers are also full of stories about the new summer "blockbuster" at the movies, Top Gun: Maverick, which is about an unreal American one.
Apart from the sources I will provide below, there are two books about 'Stocky'. One is a memoir authored by Michel Lavigne and Edwards. Here is a summary of, Kittyhawk Pilot: Wing Commander J.F. (Stocky) Edwards:
"This is the true inspirational story of James “Stocky” Edwards, Canada’s top living fighter pilot. The story begins in Battleford, Saskatchewan where Stocky grew up. During his childhood, shooting partridge, and working hard, Stocky learned the lessons that would serve him well during the Desert War. The story progresses through Stocky's training and then his posting over seas to the Desert War where he flew the P-40 Kittyhawk. This is the incredible story of a young Canadian who goes to war and becomes a superior pilot and leader of men."
The second book is: Kittyhawks over the Sands: the Canadians and RCAF Americans, also by Lavigne and Edwards. I will provide portions of a review below.
The books are not readily available, so it is good that "Stocky" has finally gained some recognition. A copy of Kittyhawk Pilot, which came out in 1983, is found in the Western Libraries, but not in many other Ontario universities. A few of them have purchased the more recent Kittyhawks Over the Sands..., but Western does not have a copy. Neither book is available in the London Public Library System. Limited copies of both books are found on used books sites, but they are very expensive.
Sources:
The Washington Post article: " "Stocky Edwards, Canadian Flying Ace in World War II, Dies at 100: He Was Heralded His Nation's "Top Gun" Over the North American Desert in 1942 and 1943," Phil Davison, May 21, 2022.
The London Free Press contains an obituary on May 20 which originated in the Comox Valley Record, a newspaper that provides other good material about Edwards. See: "World War II Flying Ace Stocky Edwards Laid to Rest," Mike Chouinard, May 20, 2022; "Comox War Hero Dies at Age 100," Scott Stanfield, May 16, 2022 and "Comox Centenarian Stocky Edwards Reflects on Years," Erin Haluschak, June 4, 2021.
For a good biographical profile see the website of Canada's Aviation Hall of Fame: "James Francis Edwards."
For a review of Kittyhawks Over the Sands... see this one by Rob Tate: Air & Space Power Journal, Vol. 17, No.4, Winter, 2003. A portion follows:
Canadian author Michel Lavigne has again teamed with the exceptional Canadian ace James "Stocky" Edwards, a retired wing commander, to produce their second book. (In 1983 they joined forces to write Kittyhawk Pilot, Edwards's biography.) Lavigne's latest work, the fourth book he has coauthored, gives historians a superb account of this fascinating subject. Readers should note, however, that Kittyhawks over the Sands is by no means an easy read and not the type of book that lends itself to casual reading; rather, the sheer volume of material makes it a reference work...
"Unlike Fighter's over the Desert, which steps through the North African campaign in a day-by-day format, Kittyhawks over the Sands focuses on Canadian pilots who flew for the Royal Air Force (RAF), Canadian and American pilots who flew for the Royal Canadian Air Force (RCAF), and squadrons that flew the American-built P-40. Thus, the book deals with the 94, 260, 112, and 250 Squadrons of the RAF and 450 Squadron of the Royal Australian Air Force (RAAF)-specifically, their battles with the Italians and the German Luftwaffe in North Africa. Lavigne and Edwards present a staggering amount of information about each squadron, including unit histories, casualties, and claims. For example, the data on casualties includes the date, type of aircraft flown, pilot's name and fate, source of shootdown, and location of the battle. For claims, they include date, time, name and nationality of the victorious pilot, type of aircraft shot down, and battle location. Throughout the book, readers will find pilot profiles, anecdotes, and 350 black-and-white photographs as well as 16 color pages of aircraft and pilots. In addition to historical information about the squadrons, the book offers appendices covering the combat records of P-40 units, P-40 aces, Canadian and American RCAF casualties, and claims made by Canadian and American RCAF pilots....
Perhaps what I like the most about Kittyhawks over the Sands are the pilot accounts and stories of aerial combat, ground attack, and pilot losses from both sides. Lavigne and Edwards intriguingly piece together air combats, including photographs of men who shot each other down and of aircraft destroyed later in the campaign. I also admire their brutally honest treatment concerning instances of over claiming by the RAF, RCAF, RAAF, and Luftwaffe. For example, on the one hand, although RAF 112 Squadron claimed 211 aircraft destroyed between June 1940 and May 1943, the authors' research corroborates only 100 to 110. On the other hand, the claim of 65.5 victories by 260 Squadron (Edwards's unit) from June 1941 to May 1943 is almost completely verifiable, demonstrating the book's historical objectivity and desire to present the most accurate and unbiased information possible."
The Bonus:
In another review of Kittyhawks.... one learns this:
"War writer Michel Lavigne of Victoriaville, Que., in his 2002 book Kittyhawks over the Sands - The Canadians and the RCAF Americans, makes a valiant effort to have these men and their desert air war remembered....
They flew Kittyhawk fighters and decorated the noses with painted-on sharks teeth.
They were the first to do that, but the American Flying Tigers of the Pacific war are best remembered for airplane teeth, thanks to the American style of focusing on heroes.
Factoid: Of the 367 Medal of Honor winners buried in Arlington National Cemetery in Virginia, nine are Canadians. The award was struck during the American Civil War and since then some 3,475 have been awarded - 61 of them to Canadians." (rev. by Dan Brown in the Ottawa Citizen, Sep. 12, 2011.)
For local readers it should be noted that 'Stocky' was stationed for a bit at RCAF Station Centralia which closed in 1967. I attended a party not long after it closed that was hosted by a member of the military whose family was housed at the former base.
Also, those interested in the subject of aviation history will find in the Archives and Special Collections up at Western the, Beatrice Hitchins Memorial Collection of Aviation History. I could not find much information about it, but some background is likely found in: Catalogue of The Beatrice Hitchins Memorial Collection of Aviation History: Presented by the Family of Fred H. Hitchins. The Catalogue, was created by Marvin Hopkinson, whose position I assumed in the Western Libraries.
I did find this useful information at Canada's Aviation Hall of Fame, under the entry for Fred Harvey Hitchins.
"Fred Harvey Hitchins, CD.**, B.A., M.A., Ph.D, was born on July 10, 1904 in London, Ontario. He attended the University of Western Ontario, London, earning his BA in 1923 and MA in 1925. He graduated from the University of Pennsylvania in 1928 with a Ph.D in history. He then joined the faculty of New York University in 1928 where he taught European history. His deep interest in aeronautical history, particularly the Canadian operations of World War I, led him to publish articles on the subject as early as 1931....
He died in London, Ontario on November 3, 1972. The importance of his work has not diminished: his papers and books were donated by his family to the University of Western Ontario as the Beatrice Hitchins Memorial Collection of Aviation History, available for generations of aviation historians to follow."
For another post related to air warfare (in Vietnam) see the one about Senator John McCain which includes a review of a book about pilots who flew from aircraft carriers during the war in Vietnam.
Wednesday, 23 January 2019
Russell Baker (August 14, 1925 - Jan. 21, 2019)
You youngsters will find it hard to believe that in the last century there used to be many newspapers and it was usually fun reading them. Columnists could be both funny and harshly critical and one of them, Russell Baker, wrote a "casual column without anything urgent to tell humanity." It has just been reported that Mr. Baker died at the age of 93. You should read him and you still can. The university close by has several of his books and the London Public Library has a few, including So This is Depravity, a title which should attract you.
Sources:
Monday, 26 November 2018
RICKY JAY

Ricky Jay died in Los Angeles on Nov. 24th. I knew little about him until I did a post about this book which he wrote: Matthias Buchinger: 'The Greatest German Living'. He (Jay) was a very interesting person and you can learn about him quickly by reading this article by Anita Gates: "Ricky Jay, Gifted Magician, Actor and Author, is Dead at 70," New York Times, Nov. 25, 2018. I have also pasted below the biographical information available on his website since it will probably disappear. In some of the interesting articles about him there is mention of the Mulholland Library of Conjuring and the Allied Arts, which should itself be worth a post-or-two.
Ricky Jay: the Serious Bio
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Sunday, 26 August 2018
Senator John McCain
It would be difficult to find anyone, other than the current President of the United States, who did not think that Senator John McCain was an honourable man who dedicated his life to serving his country. From one of the obituaries I read today, I have extracted a small portion which relates to his military career and an unfortunate event he experienced prior to the very unfortunate one he lived as a prisoner of war for over five years.
“Sen. McCain requested and got orders to do a Vietnam combat tour, joining a squadron on the supercarrier Forrestal in the Tonkin Gulf. On July 29, 1967, having flown five uneventful bombing runs over North Vietnam, he was preparing for takeoff when a missile accidentally fired from a nearby fighter struck the fuel tank of his A-4 Skyhawk, Sen. McCain wrote in his memoir. It set off explosions and a fire that killed 134 crewmen, destroyed more than 20 planes and disabled the ship so severely that it took two years to repair.
His own injuries being relatively — and miraculously — minor, Sen. McCain, then a lieutenant commander, volunteered for dangerous duty on the undermanned carrier Oriskany. He joined a squadron nicknamed the Saints that was known for its daring; that year, one-third of its pilots would be killed or captured.
(“John McCain, ‘Maverick’ of the Senate and Former POW, Dies at 81," By Karen Tumulty, Washington Post, August 26, 2018.)
The name “Oriskany” reminded me of a review I wrote over 30 years ago of a book about that carrier and the experience of those who served on it. The review is presented below and the book will be of interest to those who want to learn more about the pilots, like McCain, who fought in the air war in Vietnam.
Zalin Grant. Over the Beach: The Air War in Vietnam. W.W. Norton & Company, 1986.
The author of Over the Beach served in Vietnam and then reported from there as a journalist for Time and The New Republic. While working on a story in 1966, Mr. Grant met the members of Squadron 162 who flew off the carrier Oriskany. Intrigued by the exploits of the Naval aviators, the author kept in touch and, in 1971, located the surviving members and interviewed a number of them. The time was not right and readers were not ready, however, at least in his judgement, for the type of story that Mr. Grant wanted to tell, so the project was delayed until 1984, when the author again traced down the pilots and further recorded their experiences. So the book that has resulted is based on research, some of which was conducted twenty years ago, on the recorded reminiscences of the participants and on an analysis of some of the scholarship that was produced in the intervening years. It is partly an oral history, partly an exercise in the “New Journalism,” and it is totally satisfying.
Over the Beach recounts the history of one squadron of Naval pilots who flew F-8 Crusaders off the deck of the Oriskany as she cruised in an area known as “Yankee Station” in the Gulf of Tonkin during the period 1966 to 1972. Personal experiences are emphasized, and the reader learns a great deal about how the aviators were trained, how they viewed combat, how they lived within the confined space of “officer’s country” and how they behaved while on liberty or when captured by the enemy. Scattered throughout the book are the words of wives and, in particular, the moving recollections of the wife of one pilot who was shot down and killed. Those who approach this book expecting prose overwhelmed by military acronyms and the jargon typically uttered by men who say “Negative” when they mean ”No” will be pleasantly surprised by the eloquence of the testimony.
Although the author’s primary purpose was to tell the personal stories of pilots and “to write about them in human terms,” he does not ignore the larger political and military issues. The basic goal of the air war was to stop the flow of men and supplies into South Vietnam. However, it was not quite this simple. The strategies that were designed by military officers and politicians to accomplish this goal often differed from each other. Grant does a good job of discussing how the political restrictions that were imposed affected the course of air operations and the lives of the pilots who actually had to fly missions at particular times against particular targets, both of which were chosen by politicians thousands of miles away.
One is impressed when reading the book by the complexity of air operations and the courage it takes to perform them. It is not easy to coordinate the activities of several floating cities and it takes considerable skill to drive a huge piece of machinery off the deck of an aircraft carrier. It also takes considerable nerve to fly from a carrier and return to it at night through the rain, clouds and mist of a monsoon and land on a very small deck pitching and rolling in a heavy sea. And it takes still more courage and skill when one misses and misses again, to fly back into the night and find a tanker and refuel so one can once more try to land. The number of deaths recorded in this book from accidents alone is staggering and one does not have to be an actuary to realize that Naval aviators were involved in a very risky profession.
About ten years ago, Tom Wolfe also wrote about Naval carrier pilots in an interesting essay titled, “The Truest Sport: Jousting With Sam and Charlie,” which was reprinted in Mauve Gloves & Madmen, Clutter & Vine and in The Purple Decades. It was his goal, he wrote elsewhere, “to give the full objective description, plus something for which readers had always to go novels and short stories; namely, the subjective or emotional life of characters.” The author of Over the Beach would, I think, agree with this statement. In any case, he has written a book about those who possess “the right stuff” and anyone interested in contemporary American Studies is certain to enjoy it. Jerry Mulcahy
Canadian Review of American Studies, January 1987, 18(4), p.562
Post Script
McCain is not mentioned in Over the Beach, but the author, Zalin Grant, does offer a good account of McCain's naval experiences here: http://www.pythiapress.com/wartales/McCain-Shootdown.htm
McCain's father and grandfather were admirals and he requested a tour in Vietnam. I did not and then refused to serve there. It should not seem odd, however, that I can admire the man and do. As far as I am concerned, candidate Trump's remark about McCain should have ended his run for office and I remain surprised that so many Republican patriots were silent (and still are).
In the review, Tom Wolfe is quoted and he is now also gone. Among other things he should be remembered for giving us 'radical chic", long before 'virtue signalling' became fashionable.